Genotyping of mannose-binding lectin (MBL2) codon 54 and promoter alleles in Egyptian infants with acute respiratory tract infections

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Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood.

CONTEXT Hospital-based studies have found that increased susceptibility to certain infections is associated with low serum levels of mannose-binding lectin (MBL) due to MBL variant alleles. However, the contribution of MBL insufficiency to incidence of common childhood infections at a population level is unknown. OBJECTIVE To investigate the effect of MBL insufficiency on risk for acute respi...

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Otitis media (OM) is the most common childhood disease. Almost all children experience at least one episode of otitis media with effusion (OME) or acute otitis (OMA) during childhood, and a substantial subgroup is confronted with recurrent episodes. If not treated adequately, OM may lead to temporary or permanent hearing loss. It is well known that bacteria and viruses cause OMA, and may play a...

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Mannose-binding lectin deficiency and respiratory tract infection.

Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility to infectious disease. MBL binds numerous respiratory pathogens but the capsule...

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Mannose-Binding Lectin Codon 54 Gene Polymorphism and Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in the MBL2 gene, particularly at codon 54 (variant allele B; wild-type allele designated as A), impact upon host susceptibility to Candida infection. This systematic review and meta-analysis were performed to assess the association between MBL2 codon 54 genotype and vulvovagi...

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Mannose-binding lectin gene codon 54 polymorphism susceptible to brucellosis in Turkish children.

Genetic factors are as important as environmental factors in susceptibility to brucellosis. Among these genetic factors, mannose-binding lectin (MBL) deficiency contributes to susceptibility to animal brucellosis. The aim of the study is to determine the influence of codon 54 polymorphisms in the MBL gene on susceptibility to brucellosis. Forty-three patients diagnosed with brucellosis and 106 ...

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ژورنال

عنوان ژورنال: Egyptian Journal of Medical Human Genetics

سال: 2014

ISSN: 1110-8630

DOI: 10.1016/j.ejmhg.2013.10.002